Thus, Warframes were created out of the Helminth strain of the Infestation. As such, the Orokin discontinued their research on the Infestation.ĭuring The Old War, the Orokin Empire was desperate in defeating their Sentient adversaries, so they rebooted Infestation research to find ways to weaponize the parasite against their enemy. However, Infested outbreaks occurred, presumably caused by failures in the containment of these creatures, and ravaged the Empire's colonies across the Origin System. Led by Infested biologist Silvana, these experiments were an attempt to be rid of the toxic atmosphere that plagued the planet, maybe caused by the Empire's excessive pollution and overconsumption of natural resources. At some point in time, the Orokin performed experiments on the Infestation on Earth, uninhabitable to humans due to its toxic atmosphere. However, it is the only mention of 'Great Plague' throughout the game.ĭuring the Orokin era, before The Old War, the Infestation was created from the Orokin Empire's technological advances in biotechnology. The Mire's resemblance to the Infested suggests a connection between the Great Plague and the Infested themselves. The Great Plague may be a reference to the Infestation itself or a period after its creation. The Mire references something called the ' Great Plague' in its description. Not even the Orokin themselves are immune to it, as shown by the Entrati family, although they managed to keep their consciousness at least partially intact. As such, Warframes were often used to quell Infested outbreaks in the past. Much of the game's lore is presented in an ambiguous fashion however it can be inferred that the virus seems to have no prejudices as to whom it affects, be it Grineer, Corpus, robotic or the normal fauna of a planet only the Tenno and their Warframes, as well as the Sentients themselves, appear to be truly immune to the plague. In the past, the Infestation was utilized by the Orokin to combat the Sentients.

Mentioned and referenced through in-game text or by the Lotus, the Infestation turns organisms such as the Grineer and Corpus, as well as machines and robotics, into what is known to the Tenno as the 'Infested'. The eldest individuals, the Infested Ancients, are creatures overtaken by the plague so long ago that their original form is unrecognizable, perhaps dating back to the Old War itself.

The majority of Infested are former Corpus Crewmen or Grineer Lancers, or 'Mutalist' versions of Corpus robotic proxies. The Infested are a multitude of deformed, twisted creatures, originated from the mutation of normal living beings who have been taken over by the techno-organic parasites of the Infestation, a biomechanical pathogen created by the Orokin.

Infested duran portrait